Tag Archives: apoptosis

Signal Transduction and Apoptosis

Last lesson we learned about the different types of signalling molecules (plant and animal hormones, neurotransmitters, cytokines and phermones). Today we will learn what happens when these signalling molecules reach their target cells, causing a response in the cell. Lipophobic (hydrophilic) signalling molecules cannot pass through the cell membrane, so they rely on complementary protein receptors that are embedded in the cell membrane. Once the signalling molecule – or ligand – binds to the receptor protein, secondary messenger molecules are released inside the target cell. Learn more about the specifics of signal transduction here:

Signal transduction from the Penguin Prof Channel

Signal transduction from Mr Bozeman (simple animated diagrams with commentary)

In the video above, observe one of the consequences of signal transduction – apoptosis or programmed cell death.

Apoptosis – programmed cell death

“Apoptosis is a process where a cell is degraded in order for it to be ultimately engulfed and recycled. Apoptosis can occur when a cell has become mutated and is on the verge of becoming a cancer. Apoptosis is also the reason why we don’t have webbed hands and feet. What basically happens is that the killer “t” cell communicates with the diseased cell by adhering to it by binding its death ligand to the death receptor on the diseased cell. This causes adapter proteins to attach to the cytosolic side of the receptor. This leads to a signal cascade which involves the recruitment of various other proteins and ultimately results in the death of the cell.” ~ bowlerdude on YouTube.

  1. What is the difference between apoptosis and necrosis?
  2. What is the difference between apoptosis and autophagy?

 

 

Cell membranes and organelles

plant_cells

Image source

Key knowledge:

  • Understand the extent of the plasma membrane in forming a series of membraneous channels for the packaging and transport of biomolecules throughout eukaryotic cells.
  • Enhance knowledge and understanding of the structure and function of cell organelles.
  • Distinguish the different ways in which biomolecules enter or leave cells.
  • Develop knowledge and understanding of connections between cells.
  • Extend understanding of apoptosis.

Digital resources:

Possible Tasks:

  1. Create a “Thinglink” interactive image, labelling the different parts of a eukaryotic cell.  
  2. Create a database of terms and definitions on Quizlet. 
  3. Decorate a cake to show the different organelles of a plant or animal cell. Label with toothpick flags.
  4. Create a video describing the different forms of active transport using “common craft” style or 3D animation.
  5. Create a labelled model of the “phospholipid bilayer with integral and peripheral proteins”.